Int J Gynaecol Obstet ; Placental malaria.
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Malaria In Pregnancy: Deadly parasite, Susceptible host.
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For general information, Learn About Clinical Studies. Febrile hospitalized children aged 0 - 10 years , including those with positive and negative blood smears for P. Febrile non-hospitalized children aged years with non-severe malaria will be recruited at outpatient clinics in Ouelessebougou district health hospital and nearby facilities, with no chronic or serious illness. A participant will be excluded from the study if any one or more of the following criteria are met:.
Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information. Search for terms x. Save this study. Warning You have reached the maximum number of saved studies Listing a study does not mean it has been evaluated by the U.
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Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Last Update Posted : May 30, See Contacts and Locations. Study Description. Malaria caused by Plasmodium falciparum continues to be a global problem with devastating consequences.
A greater understanding of the immunologic and parasitologic factors associated with infection and disease is badly needed, and will accelerate the development of highly protective vaccines for both mothers and children. Pregnancy malaria is associated with low birth weight, maternal anemia, and gestational hypertension, and both inflammation and the fetal response to infection may contribute to these poor outcomes.
Childhood malaria is a major cause of mortality, and we have found that risk of childhood malaria is related to in utero exposure to pregnancy malaria, as well as other host factors like iron status and constitutive cytokine levels. Pregnancy malaria is caused by a distinct parasite binding phenotype, and as our primary hypothesis in this study we speculate that severe childhood malaria parasites may also have distinct features.
Malaria In Pregnancy Deadly Parasite, Susceptible Host by Patrick E. Duffy
A longitudinal cohort study will be conducted in Ouelessebougou, Mali an area of intense seasonal transmission. Up to pregnant women and their infants and children ages 0 - 3 will be enrolled and followed to age 5 years, with clinical evaluation and periodic venous and peripheral blood samples obtained.
In addition, febrile children up to age 10 years will be enrolled at the Ouelessebougou district health centers or the Gabriel Tour SqrRoot Copyright Pediatric Hospital in Bamako, Mali, with acute and convalescent samples being obtained and pregnant women enrolled at the health centers and hospital in Ouelessebougou district or the Gabriel Tour SqrRoot Copyright Hospital in Bamako for a case-control study on pregnancy malaria and preeclampsia.
Clinical, parasitologic and host response including immunologic endpoints will be analyzed using appropriate statistical methods, including possible confounders, to determine factors associated with infection and disease in pregnant woman and young children.
In addition, febrile hospitalized and non-hospitalized children up to age 10 years will be enrolled at the Ouelessebougou district health centers or the Gabriel Tour SqrRoot Copyright Pediatric Hospital in Bamako, Mali, with acute and convalescent samples being obtained and pregnant women enrolled at the health centers and hospital in Ouelessebougou district or the Gabriel Tour SqrRoot Copyright Hospital in Bamako for a case-control study on pregnancy malaria and preeclampsia.
- A brief review on features of falciparum malaria during pregnancy;
- Malaria in Pregnancy: Deadly Parasite, Susceptible Host | NHBS Academic & Professional Books.
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Outcome Measures. Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. INCLUSION CRITERIA: A study participant must satisfy the following criteria to be enrolled in this study: Pregnant women aged years and their newborn infants who are residents of the district of Ouelessebougou for at least one year at the time of enrollment; OR Children aged 3 years or less, who are residents of the district of Ouelessebougou for at least one year at the time of enrollment; OR Febrile hospitalized children aged 0 - 10 years , including those with positive and negative blood smears for P.